• 
  Jean-Pierre Jeunet

  regizor

• 
  Sigourney Weaver

  Ripley
• 
  Winona Ryder

  Call
• 
  Ron Perlman

  Johner
• 
  Dominique Pinon

  Vriess
• 
  David St. James

  Surgeon
• 
  Dan Hedaya

  Gen. Martin Perez
• 
  Michael Wincott

  Frank Elgyn

• 
  Raymond Cruz

  Vincent Distephano
• 
  Tom Woodruff Jr.

  Lead Alien
• 
  Brad Dourif

  Dr. Jonathan Gediman
• 
  Rico Bueno

  Sleeper
• 
  J.E. Freeman

  Dr. Mason Wren
• 
  Gary Dourdan

  Christie
• 
  Daniel Raymont

  Soldat

• 
  Leland Orser

  Larry Purvis
• 
  Archie Hahn

  Newborn Vocal #2
• 
  Kim Flowers

  Sabra Hillard
• 
  Steven Gilborn

  Voice of 'Father'
• 
  Marlene Bush

  Scientist
• 
  Carolyn Campbell

  Anesthesiologist

• 
  David Giler

  producător
• 
  Darius Khondji

  imagine
• 
  Jerry Goldsmith

  coloană sonoră
• 
  John Frizzell

  coloană sonoră