• 
  Scott Grimes

  Steve Smith (voice)
• 
  Seth MacFarlane

  Stan Smith / Roger the Alien (voice)
• 
  Wendy Schaal

  Francine Smith (voice)
• 
  Fred Savage

  Adoptive Father (voice)
• 
  Curtis Armstrong

  Snot Lonstein (voice)
• 
  Dee Bradley Baker

  Klaus (voice)
• 
  Amick Byram

  (voice)
• 
  Jeff Fischer

  Jeff Fischer (voice)

• 
  Kevin Michael Richardson

  Principal Lewis (voice)
• 
  Khary Payton

  Prison Guard (voice)
• 
  Rachael MacFarlane

  Hayley Smith (voice)
• 
  Annie Mumolo

  Adoptive Mother (voice)
• 
  Ross Marquand

  (voice)
• 
  Donna Medine

  (voice)
• 
  Baraka May

  (voice)

• 
  Nicole Shabtai

  Esther Lonstein
• 
  Sally Stevens

  Sauce Jingle Singer
• 
  Fred Tatasciore

  Modeling Advertiser