• 
  Scott Grimes

  Steve Smith (voice)
• 
  Seth MacFarlane

  Stan Smith / Roger the Alien (voice)
• 
  Wendy Schaal

  Francine Smith (voice)
• 
  Dee Bradley Baker

  Klaus (voice)
• 
  Rachael MacFarlane

  Hayley Smith (voice)
• 
  Paget Brewster

  Train Actor (voice)
• 
  Andrew Daly

  Memphis Stormfront (voice) (as Andy Daly)
• 
  Jeff Fischer

  Jeff Fischer (voice)

• 
  Tom Kenny

  Donald Magillicutty (voice)
• 
  Joe Lo Truglio

  General Store Customer (voice)
• 
  Chris Parnell

  Train Actor (voice)
• 
  Khary Payton

  Prince (voice)
• 
  Jon Daly

  Train Actor (voice)
• 
  William Jackson Harper

  General Store Cashier (voice)
• 
  Parker Deay

  Parker (voice)

• 
  Ron Perlman

  Bandit
• 
  Kevin Michael Richardson

  Billy
• 
  Tiya Sircar

  Train Actor