• 
  Scott Grimes

  Steve Smith
• 
  Seth MacFarlane

  Stan Smith
• 
  Wendy Schaal

  Francine Smith
• 
  Dee Bradley Baker

  Klaus
• 
  Rachael MacFarlane

  Hayley Smith
• 
  Danny Smith

  Daniel Paul Diamond Smith
• 
  Paget Brewster

  Johanna Gurney-Schaffner
• 
  Jeff Fischer

  Jeff Fischer

• 
  David Koechner

  Dick
• 
  Thomas Lennon

  Intellectual
• 
  Chris Parnell

  Doctor
• 
  Rory O'Malley

  (voice)
• 
  Matt E. Mixer

  (voice)
• 
  Chihye Chung

  (voice) (as Charlet Chung)
• 
  Jillian Bell

  (voice)

• 
  Nicole Shabtai

  Danuta
• 
  Josh Robert Thompson

  Daniel Stern