• 
  Frank Capra

  regizor

• 
  Julius J. Epstein

  scenarist

• 
  Cary Grant

  Mortimer Brewster
• 
  Priscilla Lane

  Elaine Harper / Elaine Brewster
• 
  Peter Lorre

  Dr. Einstein
• 
  Grant Mitchell

  Reverend Harper
• 
  Chester Clute

  Dr. Gilchrist
• 
  Lee Phelps

  Umpire

• 
  James Gleason (I)

  Lt. Rooney
• 
  Charles Lane

  Reporter
• 
  Leo White

  Man in Phone Booth
• 
  Josephine Hull

  Abby Brewster
• 
  John Ridgely

  Saunders
• 
  Herbert Gunn

  Undetermined Supporting Role
• 
  Jack Carson

  O'Hara

• 
  Edward Everett Horton

  Mr. Witherspoon
• 
  Jean Adair

  Martha Brewster
• 
  John Alexander

  'Teddy Roosevelt' Brewster
• 
  Vaughan Glaser

  Judge Cullman
• 
  Raymond Massey

  Jonathan Brewster
• 
  Edward McNamara

  Brophy
• 
  Garry Owen

  Taxi Cab Driver