• 
  Larry Bryggman

  John Dixon
• 
  Terri Colombino

  Katie Peretti
• 
  Ellen Dolan

  Margo Hughes
• 
  Eileen Fulton

   Lisa / ... (1,525 episodes, 1960-2010)
• 
  Don Hastings

  Bob Hughes
• 
  Kathryn Hays

  Kim Hughes
• 
  John Hensley

  Holden Snyder
• 
  Scott Holmes

  Tom Hughes

• 
  Roger Howarth

  Paul Ryan
• 
  Beth Hubbard

  Lucinda Walsh
• 
  Marie Masters

  Susan Stewart
• 
  Kelley Menighan Hensley

  Emily Stewart
• 
  Michael Park

  Jack Snyder
• 
  Tamara Tunie

  Jessica Griffin
• 
  Helen Wagner

  Nancy Hughes

• 
  Maura West

  Carly Tenney
• 
  Kathleen Widdoes

  Emma Snyder
• 
  Marie Wilson

  Meg Snyder
• 
  Colleen Zenk

  Barbara Ryan
• 
  Meg Ryan

  Betsy Stewart / Betsy Stewart Andropoulos / Betsy Montgomery
• 
  Parker Posey

  Tess Shelby (1991-1992)
• 
  Amanda Seyfried

  Lucinda Montgomery / Lucy Montgomery
• 
  Peyton List
• 
  Peter Dinklage

  Morlin
• 
  Marc Kudisch
• 
  Julianne Moore

  Frannie Hughes / Sabrina Hughes / Frannie
• 
  Alyssa Diaz

  Celia Ortega / Celia / Ceclia
• 
  Spencer Grammer

  Lucy Montgomery / dr. Lucy Montgomery / Lucy Montgomery #3
• 
  Billy Magnussen

  Casey Hughes
• 
  Marisa Tomei

  Marcy Thompson / Marcy Thompson Cushman / March Thompson
• 
  Peyton List

  Lucy Montgomery
• 
  Kristanna Loken

  Dani Andropoulous
• 
  Calista Flockhart

  Stacey
• 
  Anne Sward

  Lyla Montgomery / Lyla Montgomery Peretti / Lyla Peretti
• 
  Emmy Rossum

  Abigail Williams
• 
  Sarah Hyland

  Alison McDermott Stewart #4 (2001)