• 
  John Landis

  regizor

• 
  Eddie Murphy

  Axel Foley
• 
  Hector Elizondo

  Jon Flint
• 
  Jon Tenney

  Levine
• 
  Joey Travolta

  Giolito
• 
  Stephen McHattie

  Steve Fulbright
• 
  Theodore Borders

  Big Kid
• 
  John Singleton

  Fireman

• 
  Bob Minor

  Security Guard (in printing room)
• 
  Louis Schaefer

  Mike
• 
  Richard M. Sherman

  Wonderworld Bandleader
• 
  Robert B. Sherman

  Bar Patron
• 
  Thomas Rosales Jr.

  Car Mechanic
• 
  Lou George

  Mike
• 
  Barbet Schroeder

  Man in Porsche

• 
  George Lucas

  Disappointed Man
• 
  James T. Mack

  Rufus Rabbit
• 
  Judge Reinhold

  Det. Sgt. William 'Billy' Rosewood
• 
  Joe Dante

  Jailer
• 
  Bronson Pinchot

  Serge
• 
  Alan Young

  Uncle Dave Thornton
• 
  Dan Martin

  Cooper
• 
  Martha Coolidge

  Security Woman
• 
  Arthur Hiller

  Bar Patron
• 
  Tracy Melchior

  Ticket Booth Girl
• 
  Ray Harryhausen

  Bar Patron
• 
  Peter Medak

  Man at Corner
• 
  Nichole McAuley

  Spider Rider
• 
  Rick Avery

  Cline
• 
  Jonathan Hernandez

  Scared Boy
• 
  Theresa Randle

  Janice
• 
  Bob Pepper

  Pickup-Truck Driver
• 
  William S. Taylor

  Spider Rider
• 
  Jeannie Epper

  Spider Rider
• 
  Christina Venuti

  Disappointed Girl
• 
  Angus Young

  Uncle Dave Thornton
• 
  George Schaefer

  Mike
• 
  John Saxon

  Orrin Sanderson
• 
  Julie Strain

  Annihilator Girl
• 
  Phyllis Davis (I)

  Bar patron
• 
  Nick Hermz

  Tadross Gorilla
• 
  Michael Bowen

  Fletch
• 
  Louis Lombardi

  Snake
• 
  Gregory McKinney

  Kimbrough
• 
  Taylor Ball

  Spider Rider
• 
  Yareli Arizmendi

  Scared Kids' Mom
• 
  Al Leong

  Car Mechanic
• 
  Charles Rahi Chun

  Technician
• 
  Jimmy Ortega

  Rondell
• 
  Fred Asparagus

  Bobby
• 
  Timothy Carhart

  Ellis De Wald
• 
  Eugene Collier

  Leppert
• 
  Ousaun Elam

  Pederson
• 
  Tim Gilbert

  McKee
• 
  Lindsey Ginter

  Holloway
• 
  Gilbert R. Hill

  Insp. Douglas Todd
• 
  Ray Lykins

  Nixon
• 
  Dick Purtan

  Detroit Disc Jockey