• 
  Lawrence Guterman

  regizor

• 
  John Requa

  scenarist
• 
  Rick W. Finney

  scenarist
• 
  Glenn Ficarra

  scenarist

• 
  Jeff Goldblum

  Profesorul Brody
• 
  Elizabeth Perkins

  Dna. Brody
• 
  Tobey Maguire

  Lou (voce)
• 
  Alec Baldwin

  Butch (voce)

• 
  Sean Hayes

  Mr. Tinkles (voce)
• 
  Susan Sarandon

  Ivy (voce)
• 
  Joe Pantoliano

  Peek (voce)
• 
  Michael Clarke Duncan

  Sam (voce)
• 
  Jon Lovitz

  Calico (voce)
• 
  Charlton Heston

  Mastiff (voce)
• 
  James D. Bissell

  Fake Ticket Person at Stadium

• 
  Paul Pape

  Wolf Blitzer, CNN
• 
  Frank C. Turner

  The Farmer
• 
  Alvin Sanders

  Mason Employee
• 
  Carol Ann Susi

  Sophie's Sister
• 
  Miriam Margolyes

  Sophie the Castle Maid
• 
  Richard Steven Horvitz

  Puppy in barn
• 
  Glenn Ficarra

  Russian Blue
• 
  Gillian Barber

  Factory Receptionist
• 
  Salome Jens

  Collie at HQ
• 
  Billy West

  Ninja Cat (Devon Rex)
• 
  Myron Natwick

  Mr. Mason
• 
  Kirsten Robek

  Pie Mom
• 
  Danny Mann

  Ninja Cat (Devon Rex)
• 
  Mar Andersons

  Guard at Factory Gate
• 
  Mary Bogue

  Sophie's Sister
• 
  Doris Chillcott

  Mrs. Calvert
• 
  Alexander Pollock

  Scotty Brody
• 
  Mark Schooley

  Mason Employee
• 
  Randi Kaplan

  Sophie's Sister

• 
  Christopher DeFaria

  producător
• 
  Andrew Lazar

  producător
• 
  Warren Zide

  producător
• 
  Craig Perry

  producător
• 
  Julio Macat

  imagine
• 
  Michael Stevenson

  montaj
• 
  John Debney

  coloană sonoră
• 
  Ed Jones

  efecte speciale