• 
  Diane Ladd

  Nana
• 
  Walker Mintz

  James Hall
• 
  Lindsay McKeon

  Dr. Jessie Winship
• 
  Dirk Benedict

  Dave Wentworth
• 
  George Benedict

  William Morgan
• 
  Lindsay Bloom

  Mayor Aurora
• 
  Toni Hudson

  Jill Frost
• 
  Lindsey McKeon

  Kate Libby

• 
  Stelio Savante

  Officer Don
• 
  Richard Tyson

  John David Frost
• 
  Vernon Wells

  Hank
• 
  Jay M. Brooks

  Captain Jack
• 
  Clay Edmund Kraski

  Blitz
• 
  Julia Helbich

  Nurse Hilde
• 
  Wanda Morganstern

  Dr. Warren

• 
  Eliana Ghen

  Dr. Jessie Downey
• 
  Virginia Kirby

  Stella
• 
  Charles Green

  Dr. Laltoo
• 
  Francine Locke

  Nurse Hilde
• 
  Aiden Turner

  John
• 
  Meg Gillentine

  Shelby
• 
  Michael H. Cole

  Harpster
• 
  Chris Mayers

  Officer Vic
• 
  Vanessa Cozart

  Vivian
• 
  Mira Silverman

  Charlie (voice)
• 
  Sydney Rowen

  Ashley
• 
  Daniel Baldock

  Michael
• 
  James Hammond

  Guest at Wedding
• 
  Ethan Trace

  Orchestra Conductor
• 
  Carolann Utley

  Reporter Carol
• 
  Tasia Grant

  Katrina
• 
  John O'Hurley

  God (voice)
• 
  Emily Marie Palmer

  Emily
• 
  Cassie Jordan

  Pam (Jill's sister) (voice)
• 
  Vanessa Cozart

  Vivian
• 
  Robert Allen

  Builder Volunteer 1
• 
  Shalaco Basset

  Builder Volunteer 2
• 
  Tim Cavender

  Santa Claus
• 
  Julia Beasley

  Lad in Bakery 1