• 
  Gary Winick

  regizor

• 
  Dakota Fanning

  Fern
• 
  Julia Roberts

  Charlotte (voce)
• 
  André Benjamin

  Elwyn (voce)
• 
  Kathy Bates

  Bitsy (voce)
• 
  Steve Buscemi

  Templeton the Rat (voce)
• 
  Cedric the Entertainer

  Golly (voce)
• 
  Thomas Haden Church

  Brooks (voce)

• 
  John Cleese

  Samuel (voce)
• 
  Jennifer Garner

  Susy (voce)
• 
  Robert Redford

  Ike (voce)
• 
  Oprah Winfrey

  Gussy (voce)
• 
  Essie Davis

  dna. Arable
• 
  Louis Corbett

  Avery
• 
  Sam Shepard

  Narator

• 
  Siobhan Fallon

  Mrs. Zuckerman
• 
  Dominic Scott Kay

  Wilbur
• 
  Beau Bridges

  Dr. Dorian
• 
  Kevin Anderson

  Mr. Arable
• 
  Joel McCrary

  Sheep Group
• 
  Nate Mooney

  Lurvy
• 
  Abraham Benrubi

  Uncle the Pig
• 
  Brian Stepanek

  Sheep Group
• 
  Gary Basaraba

  Homer Zuckerman
• 
  Nicholas Bell

  Preot
• 
  Reba McEntire

  Betsy the Cow
• 
  Fred Tatasciore

  Sheep Group