• 
  Bradford May

  regizor

• 
  Mike Werb

  scenarist

• 
  Jeff Fahey

  Peter Rooker
• 
  Arnold Vosloo

  Darkman / Dr. Peyton Westlake
• 
  Darlanne Fluegel

  Dr. Bridget Thorne
• 
  Brian Paul

  Angry guest
• 
  Shawn Doyle

  Adam (Rooker henchman)
• 
  Roxann Dawson

  Angela Rooker

• 
  Von Flores

  Johnny Lee (drug dealer blown away by Rooker)
• 
  Nigel Bennett

  Nico (Rooker's #1 henchman)
• 
  John Novak

  Dist. Atty. Ryan Mitchell
• 
  Joel Bissonnette

  Mayo
• 
  Christopher Bondy

  Gibson