• 
  Shawn Levy

  regizor

• 
  Rob Liefeld

  scenarist
• 
  Fabian Nicieza

  scenarist
• 
  Rhett Reese

  scenarist
• 
  Ryan Reynolds

  scenarist
• 
  Paul Wernick

  scenarist
• 
  Shawn Levy

  scenarist
• 
  Zeb Wells

  scenarist

• 
  Ryan Reynolds

  Wade Wilson / Deadpool
• 
  Hugh Jackman

  Logan / Wolverine
• 
  Leslie Uggams

  Blind Al
• 
  Matthew Macfadyen

  Mr. Paradox
• 
  Morena Baccarin

  Vanessa
• 
  Karan Soni

  Dopinder
• 
  Brianna Hildebrand

• 
  Emma Corrin

  Cassandra Nova
• 
  Shioli Kutsuna

  Yukio
• 
  Rob Delaney

  Peter
• 
  Stefan Kapicic

  Colossus (voce)
• 
  Jennifer Garner

  Elektra
• 
  Lewis Tan

  Shatterstar
• 
  Aaron Stanford

  Pyro
• 
  Tony McCarthy
• 
  Terence Hughes
• 
  Kelly Hu

  Yuriko Oyama / Deathstrike
• 
  Ray Park

  Mortimer Toynbee / Toad
• 
  Jason Flemyng

  Azazel
• 
  Randal Reeder

  Buck
• 
  Greg Hemphill
• 
  Blake Lively

  Ladypool (voce)

• 
  Kevin Feige

  producător
• 
  Shawn Levy

  producător
• 
  Ryan Reynolds

  producător
• 
  Lauren Shuler Donner

  producător
• 
  George Richmond

  imagine
• 
  Mayes C. Rubeo

  costume
• 
  Graham Churchyard

  costume
• 
  Rob Simonsen

  coloană sonoră
• 
  Ray Chan

  design de producţie
• 
  Naomi Moore

  decoruri