• 
  Danny DeVito

  regizor

• 
  Ben Stiller

  Alex Rose
• 
  Drew Barrymore

  Nancy Kendricks
• 
  Harvey Fierstein

  Kenneth
• 
  Swoosie Kurtz

  Jean
• 
  Justin Theroux

  Coop
• 
  Danny DeVito

  narator (voce)
• 
  Maya Rudolph

  Tara

• 
  John Hamburg

  Mr. Friedman
• 
  James Remar

  Chick
• 
  Amber Valletta

  Celine
• 
  Geraldine Hughes

  Receptionist
• 
  Wallace Shawn

  Herman
• 
  Jackie Sandler

  Barman
• 
  Tim Maculan

  Terrence

• 
  Evgeniy Lazarev

  Mr. Dzerzhinsky
• 
  Michelle Krusiec

  Dr. Kang
• 
  Jenette Goldstein

  Moderator
• 
  Leyna Nguyen

  Female Newscaster
• 
  Gary Riotto

  Drug Dealer
• 
  Robert Wisdom

  Officer Dan
• 
  Eileen Essell

  Mrs. Connelly
• 
  Cheryl Klein

  Ginger