• 
  Cheech Marin

  Martin (voice)
• 
  Edward James Olmos

  Gayo (voice)
• 
  Rico Rodriguez

  Cuco (voice)
• 
  Lisa Kudrow

  Lucille
• 
  Gabriel Iglesias

  Garcia
• 
  Kate del Castillo

  Rayito (voice)
• 
  Erik Estrada

  Punch (voice)
• 
  K.C. Porter

  Karl

• 
  Adal Ramones

  Trueno
• 
  Paul Rodriguez

  Divino
• 
  Héctor Suárez

  Eddie Navarro
• 
  Aleks Syntek

  Cuco (Spanish version)
• 
  Pierre Angelo

  El Mexicano
• 
  Don Cheto

  Dovo
• 
  Grecia Villar

  Paquito

• 
  Ricardo El Mandril Sanchez

  Vovo
• 
  Ricardo El Mandril Sanchez

  Vovo
• 
  Mino D'Blanc

  Garza García (Spanish)