• 
  Jonny Lee Miller

  Sherlock Holmes
• 
  Lucy Liu

  Joan Watson
• 
  Jon Michael Hill

  Detective Marcus Bell
• 
  Aidan Quinn

  Captain Thomas Gregson (credit only)
• 
  Rob Bartlett

  Captain Dwyer
• 
  Andre B. Blake

  Security Coordinator (as André Blake)
• 
  Chris Diamantopoulos

  Jason Wood
• 
  James Frain

  Odin Reichenbach

• 
  Jordan Gelber

  Dr. Eugene Hawes
• 
  Jeff Applegate

  Todd Harris
• 
  Stephen Dexter

  Guest #1
• 
  Maddie Jo Landers

  Corinna Wood
• 
  Samantha Massell

  Beth
• 
  Nick Rehberger

  Colby
• 
  Emma Kikue

  Claire

• 
  Phumzile Sitole

  Assistant
• 
  Vincent Tumeo

  Wine Auction Attendee