• 
  Joss Whedon

  regizor

• 
  Adam Baldwin

  Jayne Cobb
• 
  Nathan Fillion

  Capitanul Malcolm Reynolds
• 
  Gina Torres

  Zoe Warren
• 
  Melinda Clarke

  Nandi
• 
  Branden R. Morgan

  Survivor (1 episode, 2002)
• 
  Gregory Itzin

  Magistrate Higgins (1 episode, 2002)
• 
  Eric Lange

  Fed (1 episode, 2002)

• 
  Kevin Gage

  Stitch Hessian (1 episode, 2002)
• 
  Andrew A. Rolfes

  Marcus Grange (1 episode, 2002)
• 
  Ron Glass

  Shepherd Book (14 episodes, 2002-2003)
• 
  Daniel Bess

  Mudder (1 episode, 2002)
• 
  Rolando Molina

  Bolles (1 episode, 2002)
• 
  Alan Tudyk

  Hoban 'Wash' Washburne (14 episodes, 2002-2003)
• 
  Summer Glau

  River Tam (14 episodes, 2002-2003)

• 
  Andy Umberger

  Dortmunder Captain (1 episode, 2002)
• 
  Jim Lau

  Puppet Theater Narrator (1 episode, 2003)
• 
  Gregg Henry

  Sheriff Bourne (1 episode, 2002)
• 
  Al Pugliese

  Amnon Duul (1 episode, 2003)
• 
  Larry Pennell

  Murphy (1 episode, 2002)
• 
  Steven Flynn

  Captain (1 episode, 2002)
• 
  Isabella Hofmann

  Regan Tam (1 episode, 2002)
• 
  Ilia Volok

  Marco (1 episode, 2002)
• 
  Richard Brooks

  Jubal Early (1 episode, 2002)
• 
  Jordan Lund

  Foreman (1 episode, 2002)
• 
  Franc Ross

  Monty Reynolds (1 episode, 2003)
• 
  Andrew Bryniarski

  Crow (1 episode, 2002)
• 
  Michael Bentt

  Viktor (1 episode, 2002)
• 
  Jamie McShane

  Man (1 episode, 2002)
• 
  Janora McDuffie

  Cabott (1 episode, 2002)
• 
  Blake Robbins

  Agent McGuinness (1 episode, 2002)
• 
  Kimberly McCullough

  Chari (1 episode, 2003)
• 
  Richard Burgi

  Lieutenant Womack (1 episode, 2003)
• 
  Bonnie Bartlett

  Patience (1 episode, 2002)
• 
  Edward Atterton

  Atherton Wing (1 episode, 2002)
• 
  Larry Drake

  Sir Warwick Harrow (1 episode, 2002)
• 
  John Eric Bentley

  Police Sergeant (1 episode, 2003)
• 
  Clement Blake

  Mudder Elder (1 episode, 2002)
• 
  Doug Savant

  Commander Harken (1 episode, 2002)
• 
  Tom Towles

  Lund (1 episode, 2002)
• 
  Joss Whedon

  Man at Funeral (1 episode, 2003)
• 
  Carl Bresk

  Wright (1 episode, 2002)
• 
  Mark Sheppard

  Badger (2 episodes, 2002)
• 
  Katherine Kendall

  The Councillor (1 episode, 2002)
• 
  Lyle Kanouse

  Salesman (1 episode, 2002)
• 
  Colin Patrick Lynch

  Radio Operator (1 episode, 2002)
• 
  Roy Werner

  Gentleman (1 episode, 2002)
• 
  Morena Baccarin

  Inara Serra
• 
  Simon Brooke

  Prod (1 episode, 2002)
• 
  Sean Maher

  Dr. Simon Tam (14 episodes, 2002-2003)
• 
  Dennis Cockrum

  Blue Glove Man #2 (2 episodes, 2002)
• 
  Benito Martinez

  Boss (1 episode, 2002)
• 
  Jewel Staite

  Kaylee Frye (14 episodes, 2002-2003)
• 
  Dwier Brown

  Durran Haymer (1 episode, 2003)
• 
  Fredric Lehne

  Ranse Burgess (1 episode, 2003)
• 
  Zac Efron

  Simon, tânăr
• 
  Michael McMillian

  Younger Hopeful (1 episode, 2002)
• 
  Morgan Rusler

  Barker (1 episode, 2003)
• 
  Michael Fairman

  Adelai Niska (2 episodes, 2002)
• 
  Christina Hendricks

  Saffron / Bridget / Yolanda Haymer
• 
  Philip Sternberg