• 
  Billy Dee Williams

  Touissant DuBois
• 
  Antonio Sabato Jr.

  Jagger Cates
• 
  Kimberly McCullough

  Dr. Robin Scorpio
• 
  Amanda Baker

  Jolene Crowell
• 
  Steve Burton

  Jason Morgan
• 
  Sonya Eddy

  Epiphany Johnson
• 
  Richard Gant

  Dr. Russell Ford
• 
  Adam Grimes

  Dr. Kyle Julian

• 
  Kent Masters King

  Dr.Lainey Winters
• 
  Ron Melendez

  Dr. Andy Archer
• 
  Minae Noji

  Kelly Lee
• 
  Tristan Rogers

  Robert Scorpio
• 
  Angel M. Wainwright

  Regina Thompson
• 
  Jason Thompson

  Dr. Patrick Drake
• 
  Carrie Southworth

   Dr. Claire Simpson (14 episodes, 2008)

• 
  Graham Shiels

  Cody Paul
• 
  Dominic Rains

  Dr. Leo Julian
• 
  Ethan Rains

  Dr. Leo Julian
• 
  Hadeel Sittu

  Barrett
• 
  Azita Ghanizada

   Dr. Saira Batra (14 episodes, 2008)
• 
  Bradford Anderson

  Damien Spinelli
• 
  Nazanin Boniadi

  Leyla Mir