• 
  Pablo Schreiber

  Master Chief
• 
  Yerin Ha

  Quan Ah
• 
  Natascha McElhone

  Dr. Catherine Halsey / Cortana
• 
  Bokeem Woodbine

  Soren-066
• 
  Charlie Murphy

  Makee
• 
  Shabana Azmi

  Admiral Margaret Parangosky
• 
  Bentley Kalu

  Vannak-134
• 
  Kate Kennedy

  Kai-125

• 
  Natasha Culzac

  Riz-028
• 
  Danny Sapani

  Captain Jacob Keyes
• 
  Olivia Gray

  Dr. Miranda Keyes
• 
  Ryan McParland

  Adun
• 
  Björn Freiberg

  ONIM 007 ONI Officer
• 
  Jen Taylor

  Cortana
• 
  Fiona O'Shaughnessy

  Laera

• 
  Tylan Bailey

  Kessler
• 
  Josette Simon

  Desiderata
• 
  Ian Pirie

  Professor
• 
  Angie Cepeda

  Violetta Franco
• 
  Johann Myers

  Reth
• 
  Burn Gorman

  Vinsher Grath
• 
  Jeong-hwan Kong

  Jin Ha
• 
  Felipe Gabriel Mariano

  Malchin
• 
  Nila Aalia

  Agathe Terne