• 
  James Marsden

  Hank
• 
  Rosario Dawson

  Jolene
• 
  Nathan Fillion

  Captain Superior
• 
  Alfred Molina

  Baron Blackout
• 
  Bobcat Goldthwait

  Jackalope
• 
  Jane Krajkowski

  Jane
• 
  Craig Robinson

  Stew
• 
  Will Sasso

  Gluttonator

• 
  Rob Riggle

  Biff
• 
  Thomas Middleditch

  Lester
• 
  Jim Gaffigan

  Old Doug (voice)
• 
  Kelly Sheridan

  Additional Voices
• 
  Ashleigh Ball

  Terri Murphy
• 
  Brian Drummond

  Old Doug
• 
  Teryl Rothery

  Additional Voices (voice)

• 
  Kazumi Evans

  Pep Girl Twin (Odyssey) (voice)
• 
  Vincent Tong

  Additional Voices (voice)
• 
  Sam Vincent

  Additional Voices (voice)
• 
  Donavon Stinson

  Nick of Time
• 
  Bobby Henwood

  Yakov
• 
  Ian Hanlin

  Slap Happy
• 
  Andrew Toth

  Chet
• 
  Donny Lucas

  Brutus