• 
  Ron Perlman

  Mickey Kaline
• 
  Jennifer Tilly

  Lola
• 
  Jacqueline Bisset

  madam Parvenu
• 
  Julia Louis-Dreyfus

  dra. Felter
• 
  Craig Bartlett

  Brainy
• 
  Dan Castellaneta

  Arnold's Grandpa
• 
  Toran Caudell

  Arnold
• 
  Sam Gifaldi

  Sid

• 
  Olivia Hack

  Rhonda Wellington Lloyd
• 
  Spencer Klein

  Arnold
• 
  Tress MacNeille

  Arnold's Grandma
• 
  Anndi McAfee

  Phoebe Heyerdahl
• 
  Justin Shenkarow

  Harold Berman
• 
  Francesca Smith

  Helga Pataki
• 
  Jamil Walker Smith

  Gerald Johanssen

• 
  Kath Soucie

  Miriam Pataki
• 
  Phillip Van Dyke

  Arnold
• 
  Steve Viksten

  Oskar Kokoshka
• 
  Christopher Walberg

  Stinky Petersen