• 
  Chelsea Kane

  Jen Sanders / Antivirus Babies
• 
  Seth Green

  Claktar / narator
• 
  Scott Chernoff

   Agent Donald French (1 episode, 2016)
• 
  J.D. Ryznar

   Agent Mark Branski (1 episode, 2016)
• 
  Justin Roiland

   Chubbie Webbers (1 episode, 2016)
• 
  Brian Wysol

  9 episodes, 2018-2019
• 
  Ming-Na Wen

   Soo Park / ...
• 
  Ernie Hudson

  Jet Jr.

• 
  Eric Bauza

  Nostril
• 
  Michael McCafferty

  Agent Magafferty
• 
  Derek Waters

  Matt
• 
  Debi Derryberry

  Jen's Mom
• 
  Nick Corirossi

  Blozark
• 
  Chris Tallman

  Brett Bryce
• 
  Jeffrey Combs

  Captain Moldmug

• 
  Willy Roberts

  Agent Garcia
• 
  Bennie Arthur

  Agent Benny
• 
  Esmé Bianco

  Professor Lane
• 
  Steve Blum

  Porcelini Man