• 
  Tony Leondis

  regizor

• 
  Chris McKenna

  scenarist

• 
  John Cusack

  Igor (voce)
• 
  Sean Hayes

  Brain (voice)
• 
  Molly Shannon

  Eva (voce)
• 
  Jennifer Coolidge

  Jaclyn (voce)
• 
  Jay Leno

  King Malbert (voce)
• 
  Eddie Izzard

  Dr. Schadenfreude (voce)

• 
  Steve Buscemi

  Scamper (voce)
• 
  Christian Slater

  Dr. Schadenfreude's Igor
• 
  Matt McKenna

  Dr. Herzschlag
• 
  John Cleese

  Dr. Glickenstein
• 
  Kay Cole

  Grand Dame
• 
  Paul Vogt

  Buzz Offmann
• 
  Christopher Maleki

  Killiseum fan #6

• 
  Tony Leondis

  Killiseum Fan #4
• 
  Jess Harnell

  Announcer/Royal Guard #2
• 
  Arsenio Hall

  Carl Cristall (voce)
• 
  Robin Walsh

  Dr. Holzwurm's Igor
• 
  Myleene Klass

  Dr. Holzwurm
• 
  A. Cheron Hall

  Blind Orphan #2
• 
  Zoë Bright

  Blind Woman
• 
  Sophia Eraklis

  Blind Orphan #1