• 
  Robert Townsend

  regizor

• 
  Mark Alton Brown

  scenarist

• 
  Tim Curry

  Edward Whatsett St. John
• 
  Whoopi Goldberg

  Nurse Ethyl Washington Rue Owens (Jackie's Sister)
• 
  Jenifer Lewis

  Jackie Washington
• 
  T.V. Blake

  Antandra Washington
• 
  Chris Rock

  Chris Rock
• 
  Eddie Cibrian

  Eddie Cibrian

• 
  Tangie Ambrose

  Shaniqua Summers Wells (Jackie's Daughter)
• 
  Jason Kravits

  Wimpy Bald Man
• 
  Kyla Pratt

  Little Jackie Washington
• 
  Loretta Devine

  Snookie Tate (Jackie's Childhood Friend)
• 
  Tom Arnold

  Marvin Pritz (Jackie's Former Manager)
• 
  David Hyde Pierce

  Perry (The Deaf Rehearsal Pianist)
• 
  Scott L. Schwartz

  Fight Biker

• 
  Reynaldo Rey

  Cadillac Johnson (Retired Pimp)
• 
  Kathy Najimy

  Lola Molina (Jackie's Stalker)
• 
  Isabel Sanford

  Miss Krumes (Jackie's Play Mama)
• 
  Julie Hagerty

  Pammy Dunbar (Host)
• 
  JoBeth Williams

  Jo Face (Jackie's Vocal Coach)
• 
  Ski Carr

  Bass Player
• 
  Tony Brubaker

  Fight Biker
• 
  Alan Blumenfeld

  Ivan (Theatre Manager)
• 
  Terrence Flack

  Hospital Reporter
• 
  Robert Bailey Jr.

  Wilson Wells (Jackie's Grandson)
• 
  Loren Freeman

  Kim (Jackie's Costume Designer)