• 
  Jack Black

  Georgie
• 
  Samantha Morton

  Michelle
• 
  Denis Leary

  Wayne
• 
  Will Patton

  John Smith
• 
  Christine Mourad

  ICU Nurse
• 
  Denis Johnson

  Terrance Weber
• 
  Holly Hunter

  Mira
• 
  Billy Crudup

  FH

• 
  Ben Shenkman

  Tom
• 
  Dennis Hopper

  Bill
• 
  Greg Germann

  Dr. Shanis
• 
  Boris McGiver

  Max
• 
  Michael Shannon

  Dundun
• 
  Kevin Carroll

  Chris
• 
  John Ventimiglia

  McInnes

• 
  Steve Buck

  Richard
• 
  Mark Webber

  Jack Hotel
• 
  Carol Florence

  Abortion Clinic Nurse
• 
  Jeannie Stith

  Mental Hospital Patient
• 
  Miranda July

  Black-Eyed Nurse
• 
  Torben Brooks

  Car Crash Driver
• 
  Robert Michael Kelly

  Salesman
• 
  Antoinette LaVecchia

  Dead Man's Wife
• 
  Dierdre Lewis

  Driver's Wife
• 
  Jimmy Moffit

  Car Crash Doctor
• 
  Scott Oster

  Stan
• 
  Brooke Rachel Shive

  Beatle (as Brooke Shive)
• 
  Jesse Weaver Jr.

  Carl