• 
  Ronald Reagan

  George Gipp
• 
  Pat O'Brien

  Knute Rockne
• 
  Albert Bassermann

  Father Julius Nieuwland (as Albert Basserman)
• 
  Donald Crisp

  Father John Callahan, C.S.C
• 
  Owen Davis Jr.

  Gus Dorais
• 
  John Litel

  Committee Chairman
• 
  Nick Lukats

  Harry Stuhdreher-One of The Four Horsemen
• 
  William Marshall

  Don Miller - One of The Four Horsemen

• 
  Henry O'Neill

  Doctor
• 
  Gale Page

  Bonnie Skiles Rockne
• 
  John Qualen

  Lars Knutson Rockne
• 
  Kane Richmond

  Elmer Laydon - One of The Four Horsemn
• 
  Johnny Sheffield

  Knute - Age 7 (as John Sheffield)
• 
  Dorothy Tree

  Martha Rockne
• 
  Moreau Choir of Notre Dame

  Moreau Choir (as The Moreau Choir of Notre Dame)