• 
  Donna Mills

  Laura Donnelly Elliott
• 
  Robert Burr

  Tom Donnelly
• 
  Leslie Charleson

  Iris Donnelly
• 
  David Groh

  Simon Ventnor (1972-1973)
• 
  Leon Russom

  Joe Taylor (1972-1973)
• 
  Kate Wilkinson

  Mother Irene (1973)
• 
  Bibi Besch

  Iris Donnelly Garrison #2 (1971-1973)
• 
  Diana Douglas

  Lily Chernak Donnelly (1970-1973)

• 
  Robert Drew

  Dr. Ellis
• 
  Tom Fuccello

  Mark Elliott #5 (1972-1973)
• 
  Salome Jens

  Audrey Hurley
• 
  Suzie Kaye

  Angel Allison Chernak (1969-1973)
• 
  Abigail Kellogg

  Celia Winter (1972-1973)
• 
  Judson Laire

  Dr. Will Donnelly (1968-1973) (original cast)
• 
  Karl Light

  Dr. Burger (1970-73)

• 
  Shawn Campbell

  Ricky Donnelly (1967-1973)(original cast)