• 
  John Cromwell

  regizor

• 
  Jo Swerling

  scenarist

• 
  James Stewart

  John Horace Mason
• 
  Charles Coburn

  Joseph M. Doolittle
• 
  Carole Lombard

  Jane Mason
• 
  John Picorri
• 
  Arthur Hoyt

  Jury foreman
• 
  Lane Chandler

  Ranger on telephone

• 
  Russell Hopton

  Collins (pilot)
• 
  Irving Bacon

  Newark Radio Operator
• 
  Fern Emmett

  Farmer's wife
• 
  Monte Collins

  Juror
• 
  Tom McGuire

  aprod
• 
  Ivan F. Simpson

  Simon (Judge Doolittle's brother)
• 
  Alma Kruger

  Sister Madeline

• 
  Milburn Stone

  Newark official
• 
  Mary Field

  Johns Hopkins technician
• 
  Edgar Dearing

  Mounted policeman
• 
  Harry Davenport

  Dr. Healy
• 
  Betty Farrington

  Hospital cashier
• 
  James Conaty

  Co-Worker
• 
  Edwin Maxwell

  Messerschmidt
• 
  Cyril Ring

  Office worker
• 
  Eddie Quillan

  Conway (pilot)
• 
  Ward Bond

  Jim Hatton (pilot)
• 
  Lucile Watson

  Mrs. Harriet Mason
• 
  Louise Beavers

  Lily (cook #3)