• 
  Giuliano Montaldo

  regizor

• 
  Vincenzo Labella

  scenarist

• 
  Anne Bancroft

  Doamna Polo
• 
  Burt Lancaster

  Teobaldo Visconti / Pope Gregory X
• 
  Ken Marshall

  Marco Polo
• 
  Tony Vogel

  Matteo Polo
• 
  Ken Marshall

  Marco Polo
• 
  Denholm Elliott

  Niccolo Polo

• 
  Ian McShane

  Ali Ben Yussouf
• 
  Rossella Como

  Donna Laura
• 
  Leonard Nimoy

  Achmet (1 episode, 1982)
• 
  David Warner

  Antonio 'Rustichello' Rustico (1 episode, 1982)
• 
  Jim Lau
• 
  Marilù Tolo

  Fiammetta (1 episode, 1982)
• 
  Andrew Keir

  Old Shepherd (unknown episodes)

• 
  Gordon Mitchell

  Arnolfo (1 episode, 1982)
• 
  F. Murray Abraham

  Jacopo (1 episode, 1982)
• 
  John Houseman

  Patriarch of Aquileia (1 episode, 1982)
• 
  Jack Watson

  Sailor (1 episode, 1982)
• 
  Franco Fantasia

  Ship's Master of Arms (unknown episodes)
• 
  John Gielgud

  Doge of Venice (1 episode, 1982)
• 
  Ruocheng Ying

  Kublai Khan (1 episode, 1982)
• 
  James Hong

  Phags-pa (unknown episodes)
• 
  Mario Adorf

  Giovanni (1 episode, 1982)
• 
  Riccardo Cucciolla

  Uncle Zane (1 episode, 1982)
• 
  Beulah Quo

  Empress Chabi (unknown episodes)
• 
  Sada Thompson

  Aunt Flora (1 episode, 1982)
• 
  Georgia Slowe

  Caterina (1 episode, 1982)
• 
  Gino Santercole

  Giuseppe (unknown episodes)
• 
  Hal Buckley

  Brother William (1 episode, 1982)
• 
  Vernon Dobtcheff

  Pietro de Abano (unknown episodes)
• 
  Tony Lo Bianco

  Brother Nicholas (1 episode, 1982)
• 
  Soon-Tek Oh

  Yang Zhu (unknown episodes)
• 
  Tetsurô Tanba

  Saiamon - Japanese Potter (unknown episodes)
• 
  Renato Scarpa

  Brother Thomas (unknown episodes)
• 
  Bruno Corazzari

  Agostino
• 
  John Dicks

  Brother Philip
• 
  Jun'ichi Ishida

  Prince Chinkin
• 
  Nanni Massa

  Messer Paolo
• 
  Renato Miracco

  Bartolomeo
• 
  Gordon Mitchell

  Arnolfo
• 
  Patrick Mower

  Brother Damian
• 
  Renhua Na

  Princess Kokachin
• 
  Salvatore Puntillo

  Messer Andrea
• 
  Terry Raven

  Talib
• 
  Zaibao Yang

  Yang Ku
• 
  Bruno Zanin

  Giulio
• 
  Erkang Zhao

  Nayan
• 
  Zhengyin Cao

  Governor
• 
  Shaokang Yu

  Caidu Khan
• 
  Hesen En

  Bektor Khan
• 
  Lin Lao

  Bayan
• 
  Xiaolei Huang

  Chen Pao
• 
  Sun Shulin

  Argan
• 
  Ma Qiang

  Yeli Shue
• 
  Giulio Gaslini

  Messer Lorenzo
• 
  Agnes Chan

   Mai Li (2 episodes, 1982)
• 
  Maria Pia Colonnello

   Caterina's Nurse-Maid (2 episodes, 1982)
• 
  Kathryn Dowling

   Monica (2 episodes, 1982)
• 
  John Karlsen

   Judge (1 episode, 1983)
• 
  Henry O

   Astrologer (1 episode, 1983)
• 
  Vladek Sheybal

   Prosecuting Reverend (1 episode, 1983)
• 
  Kuan Shih

   King of Korea (1 episode, 1983)