• 
  Charles Dance

  Sir Henry Carlyle
• 
  Ian Richardson

  Dr. Joseph Bell
• 
  Aly Bain

  The Fiddler
• 
  John Bett

  Charles Doyle
• 
  Sarah Collier

  Mary Doyle
• 
  Andrew John Tait

  Eustace Stark
• 
  Alec Newman

  Thomas Neill
• 
  Tamsin Pike

  Sophia

• 
  Ralph Riach

  The Strand Editor
• 
  Joel Strachan

  Crawford
• 
  David Walker

  Baxter (as David MacDowell)
• 
  Dolly Wells

  Elspeth Scott
• 
  Sean Wightman

  Mortuary Clerk
• 
  Alan Sinclair

  Medical Lecturer
• 
  Robin Laing

  Arthur Conan Doyle