• 
  Naomie Harris

  Elizabeth Lavenza
• 
  Benedict Cumberbatch

  creatura / Victor Frankenstein
• 
  Jonny Lee Miller

  The Creature
• 
  Martin Chamberlain

  Servant
• 
  George Harris

  M. Frankenstein
• 
  Karl Johnson

  de Lacey
• 
  Will Nye

  William Frankenstein (as William Nye)
• 
  Steven Elliot

  Klaus

• 
  Jared Richard

  William Frankenstein
• 
  Ella Smith

  Gretel / Clarice
• 
  Daniel Millar

  Felix de Lacey
• 
  Daniel Ings

  Servant
• 
  Lizzie Winkler

  Agatha de Lacey
• 
  John Killoran

  Gustav / Constable
• 
  Hayden Downing

  William Frankenstein