• 
  Leven Rambin

  Chloe Hall
• 
  Jessica Lucas

  Doctor
• 
  Deena Beasley

  Receptionist
• 
  George Hampe

  Eric
• 
  Robert Buckley

  Clay Evans
• 
  Sophia Bush

  Brooke Davis Baker
• 
  James Lafferty

  Nathan Scott
• 
  Bethany Joy Lenz

  Haley James Scott (as Bethany Joy Galeotti)

• 
  Austin Nichols

  Julian Baker
• 
  Lee Norris

  Marvin 'Mouth' McFadden (credit only)
• 
  Jana Kramer

  Alex Dupré (credit only)
• 
  Shantel VanSanten

  Quinn James
• 
  Stephen Colletti

  Chase Adams (credit only)
• 
  Jackson Brundage

  Jamie Scott
• 
  Lisa Goldstein

  Millicent 'Millie' Huxtable (as Lisa Goldstein) (credit only)