• 
  Karey Kirkpatrick

  regizor
• 
  Timothy O. Johnson

  regizor

• 
  Bruce Willis

  RJ (voce)
• 
  Garry Shandling

  Verne (voce)
• 
  Steve Carell

  Hammy (voce)
• 
  Eugene Levy

  Porcul spinos Lew (voce)
• 
  Avril Lavigne

  Heather (voce)
• 
  Allison Janney

  Gladys (voce)

• 
  Wanda Sykes

  Stella (voce)
• 
  William Shatner

  Ozzie (voce)
• 
  Catherine O'Hara

  Porcul spinos Penny (voce)
• 
  Nick Nolte

  Vincent (voce)
• 
  Fred Tatasciore

  Dwayne the Exterminator/Rat #2
• 
  Jess Harnell

  Vincent/King Rat/Police Chief
• 
  Shane Baumel

  Spike

• 
  Susan Boyd

  Gladys/Mom
• 
  Debi Derryberry

  Kid
• 
  Charlie Schlatter

  Milton the Mole
• 
  Bill Farmer

  Lou / Rottweiler
• 
  Madison Davenport

  Quillo
• 
  Keith Ferguson

  Possum #1/Rat #1/Chihuahua #1
• 
  Thomas Haden Church

  Dwayne (voce)
• 
  Omid Djalili

  Tiger
• 
  Sami Kirkpatrick

  Bucky