• 
  Amanda Walker

  Elaine Deneley
• 
  Mark Williams
• 
  Adjoa Andoh

  dr. Nixon
• 
  Petra Markham

  Cissy Banks
• 
  John Bowler

  Mike Pullen
• 
  Amanda Burton

   Dr. Beth Glover (36 episodes, 1993-1995)
• 
  Esther Coles

  Kim Beardsmore
• 
  Hazel Ellerby

  Chloe White

• 
  Adrian Lukis

  Dr. David Shearer
• 
  Margery Mason

  Alice North
• 
  Gary Mavers

  Dr. Andrew Attwood
• 
  Shelagh McLeod

  Kate Preston
• 
  Maggie O'Neill

  Dr. Alex Redman
• 
  Sarah Parish

   Dawn Rudge (30 episodes, 1997-1999)
• 
  Richard Platt

  James White

• 
  Veronica Roberts

  Laura Elliott
• 
  Simon Shepherd

  Dr. Will Preston
• 
  Kevin Whately

  Dr. Jack Kerruish
• 
  Saskia Wickham

   Dr. Erica Matthews (38 episodes, 1996-1998)