• 
  Michele Knotz

  Jessie (voice)
• 
  Alyson Leigh Rosenfeld

  Sophocles (voice)
• 
  Marc Swint

  Kiawe (voice)
• 
  Sarah Natochenny

  Ash (voice)
• 
  Laurie Hymes

  Lillie (voice)
• 
  Rosie Reyes

  Lana (voice)
• 
  Billy Bob Thompson

  Mimikyu (voice)
• 
  Ken Gates

  Narrator (voice)

• 
  Jimmy Zoppi

  James / Meowth (voice)
• 
  Ted Lewis

  Giovanni (voice)
• 
  Ikue Ootani

  Pikachu (voice)
• 
  Marc Thompson

  Turtonator (voice)
• 
  Kate Bristol

  Togedemaru (voice)
• 
  Suzy Myers

  Vulpix (voice) (as Suzy Myers)
• 
  Bella Hudson

  Jessie's Wobbuffet (voice)

• 
  Abe Goldfarb

  Professor Kukui (voice)
• 
  Rebecca Soler

  Mallow (voice) (as Jessica Paquet)
• 
  Eileen Stevens

  Popplio (voice)
• 
  Roger Callagy

  Rotom Pokédex (voice)