• 
  Jacqueline Pinol

  Dr. Sofia Amaral
• 
  Shawn Ashmore

  Jack Joyce
• 
  Jules de Jongh

  Clarice Ogawa
• 
  Aidan Gillen

  Paul Serene
• 
  Dominic Monaghan

  William Joyce
• 
  Lance Reddick

  Martin Hatch
• 
  Oliver Hollis

  Prototype Guard (as Oliver Hollis-Leick)
• 
  Patrick Heusinger

  Liam Burke

• 
  Courtney Hope

  Beth Wilder
• 
  Gethin Anthony

  Jack Joyce Prototype #2
• 
  Sean Durrie

  Jack Joyce Prototype #1
• 
  Jeannie Bolet

  Clarice Ogawa (mocap)
• 
  Tim Beckmann

  (voice)
• 
  Erin Richards

  Beth Wilder Prototype
• 
  Amelia Rose Blaire

  Amy Ferraro