• 
  Russell Mulcahy

  regizor

• 
  Paul W.S. Anderson

  scenarist

• 
  Milla Jovovich

  Alice
• 
  Oded Fehr

  Carlos Olivera
• 
  Iain Glen

  Dr. Isaacs
• 
  Spencer Locke

  K-Mart
• 
  Gary Hudson

  Umbrella Captain
• 
  Ashanti

  Betty

• 
  Christopher Egan

  Mikey
• 
  Matthew Marsden

  Slater
• 
  Jason O'Mara

  Albert Wesker
• 
  Mike Epps

  L.J.
• 
  James Tumminia
• 
  Ali Larter

  Claire
• 
  Madeline Carroll

  White Queen

• 
  Joe Hursley

  Otto
• 
  Shane Woodson

  Piggy
• 
  Kirk B.R. Woller

  Scientist
• 
  Linden Ashby

  Chase
• 
  Rusty Joiner

  Eddie
• 
  Rick Cramer

  Ice Hockey/Corridor Guard
• 
  Ramón Franco

  Runty
• 
  Valorie Hubbard

  Ma
• 
  William Abadie

  French Envoy
• 
  Brian Steele

  Rancid / Tyrant
• 
  John Eric Bentley

  Umbrella Tech
• 
  Peter O'Meara

  British Envoy
• 
  Gary A. Hecker

  Tyrant Vocal
• 
  Geoff Meed

  Pock Mark
• 
  John Eric Bentley

  Umbrella Tech

• 
  Paul W.S. Anderson

  producător
• 
  Jeremy Bolt

  producător
• 
  Robert Kulzer

  producător
• 
  Joseph A. Porro

  costume
• 
  Patrick Tatopoulos

  machiaj
• 
  Charlie Clouser

  coloană sonoră