• 
  John Eng

  regizor
• 
  Norton Virgien

  regizor

• 
  Cheryl Chase

  Angelica C. Pickles (voce)
• 
  Tim Curry

  Sir Nigel Thornberry (voce)
• 
  LL Cool J

  Piki (voce)
• 
  Bruce Willis

  Spike (voce)
• 
  Chrissie Hynde

  Siri (voce)
• 
  Jack Riley

  Stuart 'Stu' Pickles

• 
  Danielle Harris

  Debbie Thornberry
• 
  Kath Soucie

  Phil DeVille / Lil DeVille / Betty DeVille
• 
  Tress MacNeille

  Charlotte Pickles
• 
  Cree Summer

  Susie Carmichael
• 
  Nancy Cartwright

  Chuckie Finster
• 
  Tara Strong

  Dil Pickles
• 
  Elizabeth Daily

  Tommy Pickles

• 
  Tony Jay

  Dr. Lipschitz
• 
  Joe Alaskey

  Grandpa Lou
• 
  Ethan Phillips

  Toa
• 
  Michael Bell

  Drew Pickles / Charles 'Chaz' Finster, Sr.
• 
  Flea

  Donnie Thornberry
• 
  Lacey Chabert

  Eliza Thornberry
• 
  Tom Kane

  Darwin
• 
  Phil Proctor

  Howard DeVille
• 
  Nancy Miller

  Chuckie Finster
• 
  Melanie Chartoff

  Didi Pickles
• 
  Julia Kato

  Kira Finster
• 
  Dionne Quan

  Kimi Finster