• 
  Joseph Sargent

  regizor

• 
  Yasiin Bey

  Vivien Thomas
• 
  Alan Rickman

  Alfred Blalock
• 
  Kyra Sedgwick

  Mary Blalock
• 
  Mary Stuart Masterson

  Dr. Helen Taussig
• 
  Gabrielle Union

  Clara Thomas
• 
  David Bailey

  The General
• 
  Charles S. Dutton

  William Thomas

• 
  Tom Townsend

  Gardian
• 
  Antonio D. Charity

  Admissions Officer
• 
  Merritt Wever

  Mrs. Saxon
• 
  Nat Benchley

  Karsh
• 
  Jim Nieb

  Intern
• 
  Thomas M. Hagen

  Doctor
• 
  Irene Ziegler

  Frances Grebel

• 
  Dan Franko

  Resident doctor
• 
  Brigid Cleary

  Vivien's secretary
• 
  Ian Bonds

  Medical Intern
• 
  Michael Ahl

  Doctor at party