• 
  Mimi Kuzyk

  1 episode, 2018
• 
  Yadira Guevara-Prip

  1 episode, 2018
• 
  Mary Wiseman

  Sylvia Tilly
• 
  Anson Mount

  Captain Christopher Pike
• 
  Milton Barnes

  1 episode, 2018
• 
  Julianne Grossman

  1 episode, 2018
• 
  Aldis Hodge

  1 episode, 2018
• 
  Doug Jones

  1 episode, 2018

• 
  Rainn Wilson

  1 episode, 2019
• 
  Joe Delfin

  1 episode, 2018
• 
  Geet Arora

  1 episode, 2018
• 
  Michelle Yeoh

  1 episode, 2018
• 
  Barbara Mamabolo

  1 episode, 2019
• 
  Robert Verlaque

  1 episode, 2018
• 
  Jonathan Watton

  1 episode, 2019

• 
  Krista Deady

  1 episode, 2018
• 
  Dave Tomlinson

  1 episode, 2018
• 
  Harry Judge

  1 episode, 2019
• 
  Annabelle Wallis

  1 episode, 2018
• 
  Lisa Auguste

  1 episode, 2018
• 
  Dan Abramovici

  1 episode, 2019
• 
  Adam Winlove-Smith

  1 episode, 2018
• 
  Hannah Spear

  1 episode, 2018
• 
  Myrthin Stagg

  1 episode, 2019
• 
  Clayton Scott

  1 episode, 2018
• 
  Sash Striga

  1 episode, 2018
• 
  Rebecca Romijn

  Number One
• 
  Ethan Peck

  Spock
• 
  Samora Smallwood

  1 episode, 2019
• 
  Jenette Goldstein

  2 episodes, 2019
• 
  Kenric Green

  Mike Burnham
• 
  Kirk R. Thatcher

  Narrator
• 
  Joy Castro

  Mom
• 
  Kyrie Mcalpin

  Young Michael Burnham
• 
  Rosa Salazar

  Captain Lynne Lucero