• 
  Irving Rapper

  regizor

• 
  John Carradine

  Bret Harte
• 
  Fredric March

  Samuel Langhorne Clemens (Mark Twain)
• 
  Frank Darien

  Toy Store Proprietor
• 
  Lew Kelly

  Pilot House Guest
• 
  Percy Kilbride

  Billings, Enterprise Typesetter
• 
  George Humbert

  Rol de o replică
• 
  Hooper Atchley

  Secretary

• 
  Joseph Crehan

  Riverboat Captain / Ulysses S. Grant
• 
  Cliff Saum

  Prospector
• 
  Richard Kipling

  Rol de o replică
• 
  Kay Johnson

  Jane Clemens
• 
  Robert Barrat

  Horace E. Bixby, Riverboat Captain
• 
  Charles Irwin

  British Reporter
• 
  Dorothy Vaughan

  Katie Leary, Twain's Maid

• 
  Frank Reicher

  Doctor in Elmira, N.Y.
• 
  Frank Mayo

  Pilot House Guest
• 
  Dick Elliott

  Spectator at Frog-jumping contest
• 
  Nana Bryant

  Mrs. Langdon
• 
  Lloyd Corrigan

  Town Citizen
• 
  Frank Wilcox

  Judge Clemens, Samuel's Father
• 
  Lynn Baggett

  Susie Clemens
• 
  Walter Hampden

  Jervis Langdon
• 
  Donald Crisp

  J.B. Pond
• 
  Bill Kennedy

  Rol de o replică
• 
  Fred Kelsey

  River Rafter
• 
  Frank Hagney

  Crew Chief
• 
  Chester Conklin

  Frog Jump Contest Judge
• 
  John 'Skins' Miller

  Cross-eyed Man
• 
  Alan Hale

  Steve Gillis
• 
  Dickie Jones

  Samuel Clemens - age 15
• 
  Christian Rub

  Jones - the Printer
• 
  Willie Best

  George, Twain's Butler
• 
  Henry Blair

  băiat
• 
  Creighton Hale

  Man with Mule
• 
  Dudley Dickerson

  Black Man
• 
  C. Aubrey Smith

  Oxford Chancellor
• 
  William Haade

  Steam Room Chief
• 
  Brandon Hurst

  Ralph Waldo Emerson
• 
  Stuart Holmes

  Man at Reception
• 
  William Henry

  Charles Langdon
• 
  Leo White

  Barber
• 
  Ernie Adams

  Pickpocket
• 
  Victor Kilian

  Higgins (Hannibal townsman)
• 
  Monte Blue

  Captain of 'Queen of Dixie'
• 
  Peter Lawford

  Young Oxford Celebrant
• 
  Sam McDaniel

  Comet Watcher
• 
  Alexis Smith

  Olivia Langdon Clemens