• 
  Carol Reed

  regizor

• 
  Irving Stone

  scenarist
• 
  Philip Dunne

  scenarist

• 
  Charlton Heston

  Michelangelo
• 
  Rex Harrison

  Pope Julius II
• 
  Diane Cilento

  Contessina de Medici
• 
  Harry Andrews

  Bramante
• 
  Fausto Tozzi

  Foreman

• 
  Maxine Audley

  Woman
• 
  Alec McCowen
• 
  Furio Meniconi

  Peasant
• 
  Venantino Venantini

  Paris De Grassis
• 
  Adolfo Celi

  Giovanni de' Medici
• 
  Carey Harrison

  Pope Julius II
• 
  Tomas Milian

  Raphael

• 
  Alberto Lupo

  Duke of Urbino
• 
  John Stacy

  Sangallo