• 
  Marc Webb

  regizor

• 
  James Vanderbilt

  scenarist
• 
  Stan Lee

  scenarist
• 
  Steve Ditko

  scenarist
• 
  Steve Kloves

  scenarist
• 
  Alvin Sargent

  scenarist

• 
  Emma Stone

  Gwen Stacy
• 
  Andrew Garfield

  Peter Parker / Omul-Păianjen

• 
  Martin Sheen

  Ben Parker
• 
  Rhys Ifans

  dr. Curt Connors / Șopârla
• 
  Annie Parisse

  dna. Van Adder
• 
  C. Thomas Howell

  Ray Cooper
• 
  Campbell Scott

  Richard Parker
• 
  Charlie DePew

  Philip Stacy
• 
  Chris Zylka

  Flash Thompson

• 
  Denis Leary

  George Stacy
• 
  Leif Gantvoort
• 
  Miles Elliot

  Billy Connors
• 
  Sally Field

  May Parker
• 
  Alan Pietruszewski
• 
  Amanda MacDonald
• 
  Barbara Eve Harris

  dra. Ritter
• 
  Chelan Simmons

  Tyler
• 
  Hannah Marks

  Missy Kallenback
• 
  Irrfan Khan

  Nels Van Adder / Proto-Goblin
• 
  Jacob Rodier

  Simon Stacy
• 
  Jake Keiffer

  Jack
• 
  Julianne Nicholson

  Mary Parker
• 
  Kevin McCorkle

  dl. Cramer
• 
  Ken Edling

  om de ştiinţă
• 
  Michael Massee
• 
  Michael Remmes
• 
  Stan Lee
• 
  Vanessa Lee Chester

  Rhonda
• 
  Embeth Davidtz

  Mary Parker
• 
  Kari Coleman

  Helen Stacy
• 
  Max Charles

  Peter Parker (Age 4)
• 
  Michael Barra

  Store Clerk
• 
  Zoey Deutch

• 
  Laura Ziskin

  producător
• 
  Matthew Tolmach

  producător
• 
  Avi Arad

  producător
• 
  Kyla Kraman

  producător asociat
• 
  John Schwartzman

  imagine
• 
  Kym Barrett

  costume
• 
  Pietro Scalia

  montaj
• 
  Alan Edward Bell

  montaj
• 
  Stan Lee

  producător executiv
• 
  Michael Grillo

  producător executiv
• 
  J. Michael Riva

  design de producţie
• 
  Leslie A. Pope

  decoruri