• 
  Brian Farnham

  regizor

• 
  Kenneth Taylor

  scenarist

• 
  Yves Beneyton

  Louis XII
• 
  Martin Potter

  Paolo Orsini (6 episodes, 1981)
• 
  Alfred Burke

  Giuliano della Rovere
• 
  George Camiller

  Juan Borgia
• 
  Ralph Michael

  Cardinal Caraffa (1 episode, 1981)
• 
  John Grillo

  Don Diego Ibanez (1 episode, 1981)

• 
  Oliver Cotton

  Cesare Borgia (10 episodes, 1981)
• 
  Tony Haygarth

  Stefano (1 episode, 1981)
• 
  Trevor Peacock

  Vitellozzo Vitelli (2 episodes, 1981)
• 
  Cyrus Elias

  Cesare's groom (1 episode, 1981)
• 
  Esmond Knight

  Cardinal Gian Battista Orsini (1 episode, 1981)
• 
  Clive Merrison

  Ascanio Sforza (6 episodes, 1981)
• 
  Geoffrey Russell

  Captain Delaroche (1 episode, 1981)

• 
  Eleanor David

  Sancia (7 episodes, 1981)
• 
  Michael Kilgarriff

  Cardinal San Severino (1 episode, 1981)
• 
  Ellis Dale

  Marco Cornaro (1 episode, 1981)
• 
  Andrew Dunford

  King Charles VIII (2 episodes, 1981)
• 
  Ralph Nossek

  Johann Burchard (9 episodes, 1981)
• 
  Marne Maitland

  Mendicant friar (1 episode, 1981)
• 
  Diane Fletcher

  Caterina Sforza (2 episodes, 1981)
• 
  Anne-Louise Lambert

  Lucrezia Borgia (9 episodes, 1981)
• 
  Ryan Michael

  Alfonso Biselli (2 episodes, 1981)
• 
  Barbara Shelley

  Vannozza Canale (7 episodes, 1981)
• 
  Nicholas Le Prevost

  Baglioni (5 episodes, 1981)
• 
  Adolfo Celi

  Rodrigo Borgia (9 episodes, 1981)
• 
  Keith Skinner

  Tommasino (1 episode, 1981)
• 
  Arnold Diamond

  Cardinal Deacon (2 episodes, 1981)
• 
  Derrick Branche

  Prince Djem (2 episodes, 1981)