• 
  John Ford

  regizor

• 
  John Lee Mahin

  scenarist

• 
  John Wayne

  Col. John Marlowe
• 
  William Holden

  Maj. Henry 'Hank' Kendall
• 
  Constance Towers

  Miss Hannah
• 
  Jack Pennick

  Sgt. Maj. 'Mitch' Mitchell
• 
  Carleton Young

  Col. Jonathan Miles, CSA
• 
  Basil Ruysdael

  The Reverend (Jefferson Military Academy)

• 
  Bing Russell

  Dunker, Yankee Soldier Amputee
• 
  Danny Borzage

  Ned
• 
  O.Z. Whitehead

  Otis 'Hoppy' Hopkins (medical assistant)
• 
  Fred Graham

  Union soldier
• 
  Russell Simpson

  Acting Sheriff Henry Goodbody
• 
  Judson Pratt

  Sgt. Maj. Kirby
• 
  Richard H. Cutting

  Gen. William T. Sherman

• 
  Hoot Gibson

  Sgt. Brown
• 
  Charles Seel

  Newton Station bartender
• 
  Stuart Holmes

  Passenger to Newton Station
• 
  William Henry

  Confederate lieutenant
• 
  Chuck Hayward

  Union captain
• 
  Denver Pyle

  Jackie Jo (rebel deserter)
• 
  Hank Worden

  Deacon Clump
• 
  Ken Curtis (I)

  Cpl. Wilkie
• 
  Strother Martin

  Virgil (rebel deserter)
• 
  Willis Bouchey

  Col. Phil Secord