• 
  Harry O. Hoyt

  regizor

• 
  Marion Fairfax

  scenarist

• 
  Lewis Stone

  John Roxton
• 
  Wallace Beery

  Prof. Challenger
• 
  Bessie Love

  Paula White
• 
  Lloyd Hughes

  Edward E. Malone
• 
  Alma Bennett

  Gladys Hungerford
• 
  Arthur Hoyt

  Prof. Summerlee

• 
  Jules Cowles

  Zambo (Roxton's servant)
• 
  Leo White

  Percy Potts
• 
  Jocko the Monkey

  Jocko
• 
  George Bunny

  Colin McArdle (as Mr. George Bunny)
• 
  Margaret McWade

  Mrs. Challenger
• 
  Bull Montana

  Ape-man (as Mr. Bull Montana)
• 
  Frank Finch Smiles

  Austin (as Mr. Finch Smiles)

• 
  Charles Wellesley

  Major Hibbard (as Mr. Charles Wellsley)
• 
  Mary the Chimpanzee

  Mary the Chimpanzee (uncredited)

• 
  Arthur Conan Doyle

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