• 
  Albert Brooks

  Dr. Norman (1 episode, 1972)
• 
  Richard Dreyfuss

  Tony Injijikian (1 episode, 1973)
• 
  Barry Van Dyke

  Announcer  (6 episodes, 1971-1974)
• 
  Tina Louise

  Customer (1 episode, 1972)
• 
  Mike Henry

  Man at admitting desk (1 episode, 1972)
• 
  Paul Lambert

  Father Flanagan (1 episode, 1971)
• 
  Elliott Reid

  Elliott (2 episodes, 1971-1972)
• 
  Fannie Flagg

  'Mike' Preston  (47 episodes, 1971-1973)

• 
  Teresa Graves

  Nurse Allen (1 episode, 1972)
• 
  George Furth

  Tom Lassiter (1 episode, 1974)
• 
  Frank Campanella

  Dominic (1 episode, 1974)
• 
  David Doyle

  Ted Atwater (4 episodes, 1971-1972)
• 
  Carl Reiner

  Announcer  (2 episodes, 1972-1973)
• 
  Dick Van Dyke

  Dick Preston (72 episodes, 1971-1974)
• 
  Liam Dunn

  Myron (1 episode, 1973)

• 
  Teri Garr
• 
  Kres Mersky

  Dr. Gooding (1 episode, 1974)
• 
  Ned Wertimer

  Don Morris (1 episode, 1972)
• 
  Margaret Avery

  Nurse Wilkinson  (1 episode, 1973)
• 
  Jacqueline Scott (I)

  Sister Bernadette (1 episode, 1971)
• 
  John Amos

  Mark Cooper (1 episode, 1972)
• 
  Reta Shaw

  Nurse (2 episodes, 1972)
• 
  Ross Elliott

  Dr. Saunders (1 episode, 1972)
• 
  Carmen Zapata

  Teela (3 episodes, 1971-1972)
• 
  Joan Blondell

  Aunt Louise (1 episode, 1973)
• 
  Hal Williams

  Pete, a Burglar (1 episode, 1972)
• 
  Joe De Santis

  Carlo (1 episode, 1973)
• 
  Monte Markham

  Mike's Ex-husband (1 episode, 1972)
• 
  Arthur Batanides

  Dr. March  (2 episodes, 1972-1973)
• 
  Regis Cordic

  Dr. Simpson (1 episode, 1973)
• 
  Bernie Kopell

  Officer Jack Jackson (1 episode, 1972)
• 
  Tom Bosley

  Mr. O'Hare (1 episode, 1971)
• 
  Hope Lange

  Jenny Preston (72 episodes, 1971-1974)
• 
  Harold Gould

  Danny Everson  (2 episodes, 1972-1973)
• 
  Marcia Rodd

  Linda (1 episode, 1971)
• 
  Nancy Dussault

  Carol Davis (47 episodes, 1971-1973)
• 
  Joyce Van Patten

  Henrietta (1 episode, 1973)
• 
  Candy Clark
• 
  Clint Ritchie

  First Cyclist (1 episode, 1971)
• 
  Doris Packer

  Darlene Foster (2 episodes, 1972)
• 
  Sorrell Booke

  Herbie Vincent  (2 episodes, 1973-1974)
• 
  Dick Van Patten

  Max Mathias  (10 episodes, 1972-1974)
• 
  Barbara Rush

  Margot Brighton (3 episodes, 1973-1974)
• 
  Cesare Danova

  Francois  (2 episodes, 1971-1973)
• 
  Eddie Bracken

  Eddie (2 episodes, 1973)
• 
  Pat Harrington Jr.

  Fred Bishop (1 episode, 1974)
• 
  Alan Rafkin

  Lt. Farraday (1 episode, 1973)
• 
  Barbara Rhoades

  Charlene (1 episode, 1973)
• 
  Ruth McDevitt

  Mrs. Ferguson (1 episode, 1973)
• 
  Dick Balduzzi

  Luchino Leonardo (1 episode, 1974)
• 
  Richard Dawson

  Richard Richardson (8 episodes, 1973-1974)
• 
  Chita Rivera

  Connie Richardson (7 episodes, 1973-1974)
• 
  Barry Gordon

  Dennis Whitehead (10 episodes, 1973-1974)
• 
  Henry Darrow

  Alex Montenez (5 episodes, 1973-1974)
• 
  Luciana Paluzzi

  Anna (1 episode, 1973)
• 
  David Huddleston

  Gordon (1 episode, 1973)
• 
  Charles Nelson Reilly

  Walter (1 episode, 1972)
• 
  Maureen Arthur

  Ginger (1 episode, 1973)
• 
  Howard Storm

  First Intern (1 episode, 1973)
• 
  Herb Edelman

  George Benson (1 episode, 1973)
• 
  Mabel Albertson

  Mrs. Preston, Dick's Mother (3 episodes, 1971-1973)
• 
  Marty Brill

   Bernie Davis (47 episodes, 1971-1973)
• 
  Angela Powell

   Annie Preston (34 episodes, 1971-1974)