• 
  Hendel Butoy

  regizor

• 
  Jim Cox

  scenarist

• 
  Bob Newhart

  Bernard (voce)
• 
  Éva Gábor

  Miss Bianca (voce)
• 
  George C. Scott

  Percival C. McLeach (voce)
• 
  John Candy

  Wilbur (voce)
• 
  Tristan Rogers

  Jake (voce)
• 
  Adam Ryen

  Cody (voce)

• 
  Russi Taylor

  Nurse Mouse
• 
  Ed Gilbert

  François
• 
  Peter Firth

  Red
• 
  Douglas Seale

  Krebbs
• 
  Robert George

  Bernard
• 
  Wayne Robson

  Frank
• 
  Bernard Fox

  Chairman/Doctor

• 
  Billy Barty

  Baitmouse
• 
  Eva Gabor

  Miss Bianca
• 
  Carla Meyer

  Faloo
• 
  Frank Welker

  Joanna