• 
  Michael Cimino

  regizor

• 
  Charles Leavitt

  scenarist

• 
  Anne Bancroft

  Dr. Renata Baumbauer
• 
  Woody Harrelson

  dr. Michael Reynolds
• 
  Christopher Masterson

  Jimmy
• 
  Betty Carvalho

  Rosa
• 
  Andy Berman

  Fellow in Oncology
• 
  Bob Minor

  Deputy Lynch

• 
  Kelly Perine

  Fellow in Oncology
• 
  Sal Landi

  Deputy #2
• 
  Talisa Soto

  Navajo Woman
• 
  Jon Seda

  Brandon 'Blue' Monroe
• 
  Jeri Arredondo

  Hospital Pharmacist
• 
  Antwon Tanner

  Smokes
• 
  Matt Mulhern

  Dr. Chip Byrnes

• 
  Brett Harrelson

  Younger Highway Patrol Officer
• 
  Andrea Roth

  Head Nurse
• 
  Harry Carey Jr.

  Cashier
• 
  Robert Downey Sr.

  Telephone Voices
• 
  Lawrence Pressman

  Agent in Charge Collier
• 
  Victor Aaron

  Webster Skyhorse
• 
  Zoe Trilling

  Mini-Mart Cashier
• 
  Gregory Scott Cummins

  Biker #2
• 
  Robert 'Bobby Z' Zajonc

  FBI Helicopter Pilot
• 
  Harper Roisman

  Mr. Vogel
• 
  Mickey Jones

  Fuzzy, Biker #1