• 
  Joseph Pevney

  regizor

• 
  William Wister Haines

  scenarist

• 
  Glenn Ford

  Barney Doyle
• 
  Ernest Borgnine

  Archer Sloan
• 
  Diane Brewster

  Jane Doyle
• 
  Sam Edwards

  Coleman - Sub Radio Operator
• 
  Robert Reed

  Woolsey
• 
  Dean Jones (I)

  Lt. Jake 'Fuzz' Foley

• 
  Philip Ober

  Adm. Samuel Setton
• 
  Virginia Gregg

  Tokyo Rose
• 
  Paul Picerni (I)

  Lt. Burt Fisher
• 
  Robert Hardy

  Lt. Redley
• 
  Frank Gorshin (I)

  Sub Crewman
• 
  Karl Lukas

  Hallert
• 
  Kimberly Beck

  Dede Doyle (age 2)

• 
  Rudy Bukich

  Sub Crewman
• 
  William Schallert

  Capt. Randy Vandercook - Skipper of the 'Bluefin'
• 
  Richard Carlyle

  Cmdr. Don Adams
• 
  L.Q. Jones

  'Hash' Benson
• 
  Don Keefer

  Ens. Ron Milligan
• 
  Fredd Wayne

  Orville 'Goldy' Goldstein