• 
  Michael Winterbottom

  regizor

• 
  Frank Cottrell Boyce

  scenarist

• 
  Gillian Anderson

  văduva Wadman
• 
  Naomie Harris

  Jennie
• 
  Steve Coogan

  Tristram Shandy / Walter Shandy / Steve Coogan
• 
  Rob Brydon

  Toby Shandy / Rob Brydon
• 
  Raymond Waring

  Trim
• 
  Keeley Hawes

  Elizabeth

• 
  Shirley Henderson

  Susannah
• 
  Paul Kynman

  Obadiah
• 
  Mark Tandy

  London Doctor
• 
  Dylan Moran

  Dr. Slop
• 
  Jack Shepherd

  Surgeon
• 
  David Walliams

  Parson
• 
  Jeremy Northam

  Mark

• 
  Benedict Wong

  Ed
• 
  Mark Williams
• 
  Elizabeth Berrington

  Debbie
• 
  Ian Hart

  Joe
• 
  Jack Shepherd

  Surgeon
• 
  Stephen Fry

  Patrick Curator/Parson Yorick
• 
  James Fleet

  Simon
• 
  Mary Healy

  Midwife
• 
  Ronni Ancona

  Anita
• 
  Greg Wise

  Greg
• 
  Kelly Macdonald

  Jenny
• 
  Kieran O'Brien

  Gary
• 
  Roger Allam

  Adrian
• 
  Justine Mitchell

  Tony's Director
• 
  Rosie Cavaliero

  Rachel
• 
  Ashley Jensen

  Lindsey
• 
  Mark Hadfield

  Leo